neuroprotective effects of epigallocatechin-3-gallate in an experimental model of alzheimer’s disease in rat: a histological study
نویسندگان
چکیده
abstract introduction: neurodegeneration change is one of the hallmark symptoms of which alzheimer’s disease (ad) can be modeled by β-amyloid injection into specific regions of brain. (-)-epigallocatechin-3-gallate (egcg) is a potent antioxidant agent that its role against oxidative stress and inflammation has been shown in prior studies. in the present study, we have wanted to determine whether egcg administration protects against β-amyloid induced cell damages in rats . methods: animals (male wistar rats) divided into four groups: sham operated (sh), egcg-pretreated sham operated (sh + egcg), untreated lesion (l), and egcg-pretreated lesion (l + egcg). animals in l, l + egcg, and sh + egcg groups received sterile saline or saline plus egcg (10 mg/kg) intraperitoneally one day pre-surgery and every other day for three weeks. the lesion was induced one day after egcg treatment by injection of water or water containing 2 nmol/µl of β-amyloid (1-40) into the hippocampal fissure. we evaluat ed the morphological changes of hippocampus specially ca3 region by nissl staining after three weeks of surgery . results: we found that β-amyloid (1-40) injection into hippocampus causes cell death of ca3 region in l group in comparison with sh group which also occurs in the alzheimer’s disease. on the other hand, treatment with egcg can improve the validity of these cells in hippocampus . discussion: we concluded that egcg could be effective in protection against pathogenesis of alzheimer’s disease .
منابع مشابه
Neuroprotective effects of epigallocatechin-3-gallate in an experimental model of Alzheimer’s disease in rat: a histological study
Abstract Introduction: Neurodegeneration change is one of the hallmark symptoms of which Alzheimer’s disease (AD) can be modeled by β-amyloid injection into specific regions of brain. (-)-Epigallocatechin-3-gallate (EGCG) is a potent antioxidant agent that its role against oxidative stress and inflammation has been shown in prior studies. In the present study, we have wanted to determine wh...
متن کاملNeuroprotective Effects of Epigallocatechin-3-Gallate in an Experimental Model of Alzheimer’s Disease in Rat: A Histological Study
متن کامل
The Beneficial Effect of (-)-Epigallocatechin-3-Gallate in an Experimental Model of Alzheimer’s disease in Rat: a Behavioral Analysis
Progressive cognitive decline is one of the hallmark symptoms of Alzheimer’s disease (AD) which can be modeled by β-amyloid injection into specific regions of brain. Since epigallocatechin-3-gallate (EGCG) is a potent antioxidant agent which its role against oxidative stress and inflammation has been shown in prior studies, we tried to determine whether EGCG administration protects against β-am...
متن کاملthe beneficial effect of (-)-epigallocatechin-3-gallate in an experimental model of alzheimer’s disease in rat: a behavioral analysis
progressive cognitive decline is one of the hallmark symptoms of alzheimer’s disease (ad) which can be modeled by β-amyloid injection into specific regions of brain. since epigallocatechin-3-gallate (egcg) is a potent antioxidant agent which its role against oxidative stress and inflammation has been shown in prior studies, we tried to determine whether egcg administration protects against β-am...
متن کاملThe beneficial effect of (-)-epigallocatechin-3-gallate in an experimental model of Alzheimer's disease in rat: a behavioral analysis.
BACKGROUND Progressive cognitive decline is one of the hallmark symptoms of Alzheimer's disease (AD) which can be modeled by beta-amyloid injection into specific regions of brain. Since epigallocatechin-3-gallate (EGCG) is a potent antioxidant agent which its role against oxidative stress and inflammation has been shown in prior studies, we tried to determine whether EGCG administration protect...
متن کاملThe Effect of Epigallocatechin gallate on Morphine Induced Working Memory Defects in Rats: An Experimental Study
Background and Objectives: Chronic morphine use leads to structural changes in the brain. Some studies have shown the antioxidant and neuroprotective effects of Epigallocatechin gallate (EGCG) as a main polyphenol of green tea. Therefore, the aim of this study was to investigate the effect of EGCG on working memory in morphine-treated rats. Materials and Methods: In this experimental study, 32...
متن کاملمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
basic and clinical neuroscienceجلد ۱، شماره ۱، صفحات ۷-۱۲
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023